Cefepime renal dosing fdating

Cefepime renal dosing fdating

Precautions Serious and occasionally fatal hypersensitivity reactions have been reported with antibiotics. The drug should be discontinued if seizures occur.

Prothrombin times should be monitored and vitamin K therapy initiated if indicated. Doses should be administered at the same time each day when possible. Nephrotoxicity has occurred with concomitant cephalosporins and aminoglycosides or potent diuretics. The maximum pediatric dose should not exceed the recommended dose for adults.

Mild cases generally improve withNeurotoxicity and renal

Renal Dose Adjustments Initial doses of cefepime in renally impaired patients except hemodialysis patients should be the same as in patients with normal renal function. Therefore, it is important to consider this diagnosis in patients who present with diarrhea following cephalosporin therapy. Cephalosporins may be associated with a fall in prothrombin activity.

Mild cases generally improve with discontinuation of the drug, while severe cases may require supportive therapy and treatment with an antimicrobial agent effective against C difficile. Neurotoxicity and renal failure have been reported, mostly in renally impaired patients receiving higher than recommended doses of cefepime. Risk factors include renal or hepatic impairment, poor nutritional state, a protracted course of antimicrobial therapy, and chronic anticoagulation therapy. Doses should be based on the estimated cefepime clearance. If the causative organism is not Pseudomonas aeruginosa, the duration of treatment should be as short as clinically possible e.

Liver Dose Adjustments No adjustment recommended. Renal function should be monitored, especially in elderly patients.